Metástasis en tejido celular subcutáneo de glioblastoma multiforme: caso clínico y revisión de la literatura / Subcutaneous tissue metastasis from glioblastoma multiforme: A case report and review of the literature

El glioblastoma multiforme es la neoplasia maligna cerebral primaria más frecuente, y a pesar de su curso agresivo, menos del 2% de los pacientes desarrollan metástasis extraneurales. Presentamos el caso de un varón de 72 años con diagnóstico de glioblastoma multiforme temporal derecho por clínica de cefalea. El paciente se intervino con resección macroscópicamente completa y se administró terapia adyuvante. Cinco meses después, reingresa por dolor trigeminal observándose en la RM una masa extracraneal infratemporal que infiltraba el espacio masticador, estructuras óseas, musculatura temporal y ganglios linfáticos cervicales superiores y parotídeos. El paciente se reintervino, alcanzándose la resección parcial de la lesión temporal, tras los cual presentaba persistencia del dolor trigeminal invalidante. Dada la mala situación funcional del paciente y el fracaso del tratamiento se decidió limitar esfuerzo terapéutico, produciéndose el exitus del paciente a las 3 semanas del diagnóstico de la afectación extracraneal

Glioblastoma multiforme is the most common primary brain tumor, despite an aggressive clinical course, less than 2% of patients develop extraneural metastasis. We present a 72-year-old male diagnosed with a right temporal glioblastoma due to headache. He underwent total gross resection surgery and after that the patient was treated with adyuvant therapy. Five months after the patient returned with trigeminal neuralgia, and MRI showed an infratemporal cranial mass which infiltrates masticator space, the surrounding bone, the temporal muscle and superior cervical and parotid lymph nodes. The patient underwent a new surgery reaching partial resection of the temporal lesion. After that the patient continued suffering from disabling trigeminal neuralgia, that's why because of the bad clinical situation and the treatment failure we decided to restrict therapeutic efforts. The patient died 3 weeks after the diagnosis of extracranial metastasis

Subcutaneous tissue metastasis from glioblastoma multiforme: A case report and review of the literature. / Metástasis en tejido celular subcutáneo de glioblastoma multiforme: caso clínico y revisión de la literatura.

Glioblastoma multiforme is the most common primary brain tumor, despite an aggressive clinical course, less than 2% of patients develop extraneural metastasis. We present a 72-year-old male diagnosed with a right temporal glioblastoma due to headache. He underwent total gross resection surgery and after that the patient was treated with adyuvant therapy. Five months after the patient returned with trigeminal neuralgia, and MRI showed an infratemporal cranial mass which infiltrates masticator space, the surrounding bone, the temporal muscle and superior cervical and parotid lymph nodes. The patient underwent a new surgery reaching partial resection of the temporal lesion. After that the patient continued suffering from disabling trigeminal neuralgia, that's why because of the bad clinical situation and the treatment failure we decided to restrict therapeutic efforts. The patient died 3 weeks after the diagnosis of extracranial metastasis.